Epitranscriptomics in the development, functions, and disorders of cancer stem cells

Linlin Hao; Jian Zhang; Zhongshan Liu; Xia Lin; Jie Guo

doi:10.3389/fonc.2023.1145766

Epitranscriptomics in the development, functions, and disorders of cancer stem cells

Front Oncol. 2023 Mar 17:13:1145766. doi: 10.3389/fonc.2023.1145766. eCollection 2023.

Authors

Linlin Hao¹, Jian Zhang², Zhongshan Liu¹, Xia Lin¹, Jie Guo¹

Affiliations

¹ Department of Tumor Radiotherapy, The Second Hospital of Jilin University, Changchun, China.
² School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen, China.

Abstract

Biomolecular modifications play an important role in the development of life, and previous studies have investigated the role of DNA and proteins. In the last decade, with the development of sequencing technology, the veil of epitranscriptomics has been gradually lifted. Transcriptomics focuses on RNA modifications that affect gene expression at the transcriptional level. With further research, scientists have found that changes in RNA modification proteins are closely linked to cancer tumorigenesis, progression, metastasis, and drug resistance. Cancer stem cells (CSCs) are considered powerful drivers of tumorigenesis and key factors for therapeutic resistance. In this article, we focus on describing RNA modifications associated with CSCs and summarize the associated research progress. The aim of this review is to identify new directions for cancer diagnosis and targeted therapy.

Keywords: RNA modification; RNA-modifying enzyme; cancer stem cell; epitranscriptomics; stemness.

Publication types

Review

Grants and funding

This work was supported by funding from the Jilin Province Financial and Health Project(A project to improve the ability to diagnose and treat gynecological oncology, 3D517EC03427), Jilin Provincial Department of Finance (CBCT bone registration was used to analyze the effect of volume rotation intensity modulation on target dose, 3D5204889429), Jilin Provincial Department of Finance (Dose-effect analysis of Zeiss intraoperative radiotherapy machine irradiating primary cultured vertebral metastases, 2019SCZT029).