Design, preparation, and in vitro evaluation of gastroretentive floating matrix tablet of mitiglinide

Meenakshi Patel; Santosh Shelke; Naazneen Surti; Prabhakar Panzade; Lamya Ahmed Al-Keridis; Tarun Kumar Upadhyay; Nawaf Alshammari; Mohd Saeed

doi:10.3389/fphar.2023.1140351

Design, preparation, and in vitro evaluation of gastroretentive floating matrix tablet of mitiglinide

Front Pharmacol. 2023 Mar 15:14:1140351. doi: 10.3389/fphar.2023.1140351. eCollection 2023.

Authors

Meenakshi Patel¹, Santosh Shelke², Naazneen Surti³, Prabhakar Panzade², Lamya Ahmed Al-Keridis⁴, Tarun Kumar Upadhyay⁵, Nawaf Alshammari⁶, Mohd Saeed⁶

Affiliations

¹ Department of Pharmaceutics, School of Pharmacy, Faculty of Pharmacy, Parul University, Waghodia, India.
² Department of Pharmaceutics, Srinath College of Pharmacy, Aurangabad, India.
³ Babaria Institute of Pharmacy, Varnama, Gujarat Technological University, Vadodara, India.
⁴ Biology Department, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
⁵ Department of Biotechnology, Parul Institute of Applied Sciences and Centre for Research for Development, Parul University, Vadodara, India.
⁶ Department of Biology, College of Sciences, University of Hail, Hail, Saudi Arabia.

Abstract

The present research is focused on developing floating matrix tablets of mitiglinide to prolong its gastric residence time for better absorption. Gastroretentive tablets were prepared using a direct compression technique with hydroxypropyl methylcellulose K15M (HPMC K15M) and sodium alginate as matrix-forming polymers and sodium bicarbonate as the gas-forming agent. A 3² full factorial design was adopted to optimize the flotation and release profile of the drug. The concentration of HPMC K15M and sodium alginate were taken as the independent variables, and the floating lag time, time required for 50% drug release, and time required for 90% drug release were taken as dependent variables. The compatibility between drug and excipients was assessed by Fourier transform infrared (FTIR) spectroscopy. The prepared tablets were evaluated for different parameters such as hardness, friability, drug content, floating time, in vitro dissolution, and stability. Dissolution data were analyzed using various kinetic models to ascertain the mechanism of drug release. Finally, a radiographic study was conducted to estimate the retention time of the optimized floating matrix tablets of mitiglinide inside the body. The results revealed that all the physical properties of the developed formulations were within standard limits. The formulation M3, with the maximum amount of both independent variables, was considered to be the optimized formulation based on the desirability value. In addition, the optimized M3 formulation showed stability for over 6 months, as evidenced by insignificant changes in lag time, drug release pattern, and other physical properties. Furthermore, radiographic examination indicated that the tablets remained afloat in gastric fluid for up to 12 h in the rabbit's stomach. In conclusion, the developed floating matrix tablet of mitiglinide could be regarded as a promising formulation that could release the drug in the stomach at a controlled rate and, hence, offer better management of type II diabetes.

Keywords: factorial design; floating matrix tablet; gastroretentive; mitiglinide; radiography.

Grants and funding

Princess Nourah bint Abdulrahman University researcher, supporting program number (PNURSP2023R82), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.