Current trends and future perspectives for enhanced drug delivery to central nervous system in treatment of stroke

Ther Deliv. 2023 Jan;14(1):61-85. doi: 10.4155/tde-2022-0064. Epub 2023 Apr 3.

Abstract

Stroke, one of the leading causes of death around the globe, is expected to rise considerably by 2050. The expanding nanotechnology science offers a promising future for medical research treating stroke. Nanomaterials are expanding their application in stroke management by structure and function as in perfluorocarbon, iron oxide nanoparticles, gold nanoparticles, dendrimers, quantum dots, nanospheres, and other organic and inorganic nanostructures. Nanotechnology integrated with stem-cell therapy is a different hit in stroke treatment. Nonetheless, some challenges must be resolved before globalizing the use of nanomaterials in stroke treatment and other neurological disorders.

Keywords: conventional therapeutic approach; fluid biomarkers; nano-technology; neuroprotection; stroke.

Plain language summary

A stroke is an emergency medical condition that affects the brain. Stroke is the third leading cause of death in the US and fifth in other developing countries. Taking blood-clotting medicines, helps relieve symptoms by preventing blood clots. However, they cannot treat the cause of the disease that is causing them. Therefore, using body fluids for identifying and treating strokes will give better results. In general, giving medicine to the brain is difficult, and it is a big challenge. Nanosized small molecules help to overcome this problem. This review aims to summarize how stroke is managed and how these molecules can help.

Publication types

  • Review

MeSH terms

  • Central Nervous System
  • Drug Delivery Systems
  • Gold
  • Humans
  • Metal Nanoparticles*
  • Nanoparticles*
  • Nanostructures* / chemistry
  • Nanotechnology
  • Stroke* / drug therapy

Substances

  • Gold