MDSCs: The Key Players in the Formation of Pre-Metastatic Niche

Weigang Cui; Ziyi Wang; Jie Lv; Yan Qin; Huifang Shi

doi:10.31083/j.fbl2803058

MDSCs: The Key Players in the Formation of Pre-Metastatic Niche

Front Biosci (Landmark Ed). 2023 Mar 20;28(3):58. doi: 10.31083/j.fbl2803058.

Authors

Weigang Cui¹, Ziyi Wang², Jie Lv³, Yan Qin³, Huifang Shi³

Affiliations

¹ Central Laboratory, The Rizhao People's Hospital Affiliated to Jining Medical University, 276826 Rizhao, Shandong, China.
² Department of Anesthesiology, The Rizhao People's Hospital Affiliated to Jining Medical University, 276826 Rizhao, Shandong, China.
³ Clinical Laboratory, The Rizhao People's Hospital Affiliated to Jining Medical University, 276826 Rizhao, Shandong, China.

PMID: 37005751
DOI: 10.31083/j.fbl2803058

Abstract

The distal metastasis of tumor cells is viewed as a series of concurrent processes rather than a linear cascade of events. Accompanied with the progression of the primary tumor, a favorable microenvironment, refered as pre-metastatic niche, has been created in pre-metastatic organs and sites by primary tumors for subsequent metastases. The proposal of "pre-metastatic niche" theory brings fresh insight into our understanding of cancer metastasis. Myeloid-derived suppressor cells (MDSCs) are indispensable for the formation of pre-metastatic niche, which empower the niche to favor tumor cell colonization and promote metastasis. In this review, we aim to provide a comprehensive understanding of the regulation of pre-metastatic niche formation by MDSCs and to conceptualize the framework for understanding the related factors involved in cancer metastasis.

Keywords: MDSCs; function; pre-metastatic niche; recruitment.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Myeloid-Derived Suppressor Cells* / pathology
Neoplasm Metastasis
Neoplasms* / pathology
Tumor Microenvironment