New insights into the function of Interleukin-25 in disease pathogenesis

Qingfang Yuan; Na Peng; Fan Xiao; Xiaofei Shi; Bo Zhu; Ke Rui; Jie Tian; Liwei Lu

doi:10.1186/s40364-023-00474-9

New insights into the function of Interleukin-25 in disease pathogenesis

Biomark Res. 2023 Apr 1;11(1):36. doi: 10.1186/s40364-023-00474-9.

Authors

Qingfang Yuan^#^{1

2}, Na Peng^#³, Fan Xiao^{4

5}, Xiaofei Shi⁶, Bo Zhu¹, Ke Rui^{7

8}, Jie Tian^{9

10}, Liwei Lu^{11

12

13}

Affiliations

¹ Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
² Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
³ Department of Rheumatology, the Second People's Hospital, Three Gorges University, Yichang, China.
⁴ Department of Pathology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Chongqing International Institute for Immunology, Chongqing, China.
⁵ Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong, China.
⁶ Department of Rheumatology and Immunology, The First Affiliated Hospital, School of Medicine, Henan University of Science and Technology, Luoyang, China.
⁷ Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. ruike@ujs.edu.cn.
⁸ Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China. ruike@ujs.edu.cn.
⁹ Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, China. tianjie@ujs.edu.cn.
¹⁰ Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China. tianjie@ujs.edu.cn.
¹¹ Department of Rheumatology, the Second People's Hospital, Three Gorges University, Yichang, China. liweilu@hku.hk.
¹² Department of Pathology, Shenzhen Institute of Research and Innovation, The University of Hong Kong, Chongqing International Institute for Immunology, Chongqing, China. liweilu@hku.hk.
¹³ Centre for Oncology and Immunology, Hong Kong Science Park, Hong Kong, China. liweilu@hku.hk.

^# Contributed equally.

Abstract

Interleukin-25 (IL-25), also known as IL-17E, is a cytokine belonging to the IL-17 family. IL-25 is abundantly expressed by Th2 cells and various kinds of epithelial cells. IL-25 is an alarm signal generated upon cell injury or tissue damage to activate immune cells through the interaction with IL-17RA and IL-17RB receptors. The binding of IL-25 to IL-17RA/IL-17RB complex not only initiates and maintains type 2 immunity but also regulates other immune cells (e.g., macrophages and mast cells) via various signaling pathways. It has been well-documented that IL-25 is critically involved in the development of allergic disorders (e.g., asthma). However, the roles of IL-25 in the pathogenesis of other diseases and the underlying mechanisms are still unclear. This review presents current evidence on the roles of IL-25 in cancers, allergic disorders, and autoimmune diseases. Moreover, we discuss the unanswered key questions underlying IL-25-mediated disease pathology, which will provide new insights into the targeted therapy of this cytokine in clinical treatment.

Keywords: Autoimmune diseases; Cancer; Clinical treatment; IL-25(IL-17E); Inflammation.

Publication types

Review

Abstract

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