Spatial epigenome-transcriptome comapping technology

Ming-Zhu Jin; Wei-Lin Jin

doi:10.1016/j.tcb.2023.03.011

Spatial epigenome-transcriptome comapping technology

Trends Cell Biol. 2023 Jun;33(6):449-450. doi: 10.1016/j.tcb.2023.03.011. Epub 2023 Mar 31.

Authors

Ming-Zhu Jin¹, Wei-Lin Jin²

Affiliations

¹ Department of Obstetrics and Gynecology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, China. Electronic address: ldyy_jinwl@lzu.edu.cn.

PMID: 37005211
DOI: 10.1016/j.tcb.2023.03.011

Abstract

Spatial omics facilitate an in-depth understanding of cell states and cell interactions. Recent work by Zhang et al. simultaneously seizes spatial epigenetic priming, differentiation, and gene regulation at nearly single-cell resolution by developing an epigenome-transcriptome comapping technology. This work displays how epigenetic features influence cell dynamics and transcriptional phenotypes at spatial and genome-wide levels.

Keywords: epigenome; gene expression; single-cell resolution; spatial omics; transcriptome.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Epigenome* / genetics
Gene Expression Regulation
Genome
Technology
Transcriptome* / genetics