External Evaluation of Population Pharmacokinetic Models for Precision Dosing: Current State and Knowledge Gaps

Abstract

Predicting drug exposures using population pharmacokinetic models through Bayesian forecasting software can improve individual pharmacokinetic/pharmacodynamic target attainment. However, selecting the most adapted model to be used is challenging due to the lack of guidance on how to design and interpret external evaluation studies. The confusion around the choice of statistical metrics and acceptability criteria emphasises the need for further research to fill this methodological gap as there is an urgent need for the development of standards and guidelines for external evaluation studies. Herein we discuss the scientific challenges faced by pharmacometric researchers and opportunities for future research with a focus on antibiotics.