Positron Emission Tomography Imaging in Vasculitis

Kornelis S M van der Geest; Berend G C Slijkhuis; Alessandro Tomelleri; Olivier Gheysens; William F Jiemy; Costanza Piccolo; Pieter Nienhuis; Maria Sandovici; Elisabeth Brouwer; Andor W J M Glaudemans; Douwe J Mulder; Riemer H J A Slart

doi:10.1016/j.ccl.2023.01.012

Positron Emission Tomography Imaging in Vasculitis

Cardiol Clin. 2023 May;41(2):251-265. doi: 10.1016/j.ccl.2023.01.012. Epub 2023 Feb 19.

Affiliations

¹ Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, the Netherlands.
² Division of Vascular Medicine, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, the Netherlands.
³ Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Milan, Italy.
⁴ Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc and Institute of Clinical and Experimental Research (IREC), Université Catholique de Louvain (UCLouvain), Brussels, Belgium.
⁵ Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Center Groningen, University of Groningen, the Netherlands.
⁶ Department of Nuclear Medicine and Molecular Imaging, Medical Imaging Center, University Medical Center Groningen, University of Groningen, the Netherlands; Biomedical Photonic Imaging Group, Faculty of Science and Technology, University of Twente, Enschede, the Netherlands. Electronic address: r.h.j.a.slart@umcg.nl.

PMID: 37003681
DOI: 10.1016/j.ccl.2023.01.012

Abstract

Systemic vasculitides comprise a group of autoimmune diseases affecting blood vessels. [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) plays an important role in the diagnosis and therapeutic monitoring of vasculitides affecting large-sized and medium-sized vessels. FDG-PET/CT also provides complementary information to other vascular imaging tools. The resolution and sensitivity of newer generation scanners continues to increase, hereby improving the ability of FDG-PET/CT to accurately assess the full disease extent in patients with vasculitis. Novel tracers targeting specific immune cells will allow for more detailed detection of vascular infiltrates.

Keywords: FDG-PET/CT; Heart; Novel tracers; Vasculitis.

Publication types

Review

MeSH terms

Fluorodeoxyglucose F18
Humans
Positron Emission Tomography Computed Tomography* / methods
Positron-Emission Tomography / methods
Radiopharmaceuticals
Vasculitis* / diagnostic imaging

Substances

Fluorodeoxyglucose F18
Radiopharmaceuticals