Five new spirosterol saponins from Allii Macrostemonis Bulbus

Chin J Nat Med. 2023 Mar;21(3):226-232. doi: 10.1016/S1875-5364(23)60423-6.

Abstract

Five new spirostanol saponins (1-5) and seven known compounds (6-12) were isolated from the n-butanol fraction of 75% ethanol extract of Allii Macrostemonis Bulbus. The identification and structural elucidation of all the isolates were performed through extensive 1D and 2D NMR experiments, HR-ESI-MS data analysis and comparisons with literature values. Antioxidant evaluation showed that compounds 6-11 exhibited certain scavenging effects on ABTS radical, where compounds 6, 7 and 11 had IC50 values of 0.208, 0.057 and 0.014 mg·mL-1, respectively.

Keywords: Allii Macrostemonis Bulbus; Antioxidant; Spirosterol saponin.

MeSH terms

  • Antioxidants / pharmacology
  • Drugs, Chinese Herbal* / chemistry
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Saponins* / chemistry
  • Saponins* / pharmacology

Substances

  • allii macrostemonis bulbus
  • Saponins
  • Drugs, Chinese Herbal
  • Antioxidants