Design and application of potentiometric sensors for the determination of mefenamic and phenylanthranilic acids

Zholt Kormosh; Yuriy Khalavka; Susheel K Mittal

doi:10.1039/d2ay02092k

Design and application of potentiometric sensors for the determination of mefenamic and phenylanthranilic acids

Anal Methods. 2023 Apr 13;15(15):1903-1914. doi: 10.1039/d2ay02092k.

Authors

Zholt Kormosh¹, Yuriy Khalavka², Susheel K Mittal³

Affiliations

¹ Department of Chemistry and Technology, Lesya Ukrainka Volyn National University, Voli Av., 13, 43021 Lutsk, Ukraine. kormosh@vnu.edu.ua.
² Department of Inorganic Chemistry of Solids and Nanoparticles, Yuriy Fedkovych Chernivtsi National University, Kotsiubynsky Str. 2, 58012 Chernivtsi, Ukraine.
³ School of Chemistry and Biochemistry, Thapar University, Patiala, Punjab 147004, India. smittal@thapar.edu.

PMID: 37000565
DOI: 10.1039/d2ay02092k

Abstract

Characteristics, performance and applications of potentiometric membrane sensors are described for the determination of mefenamic and phenylanthranilic ions. Ion associates of mefenamic, ClO₄^-, and phenylanthranilic ions with crystal violet (counter-cation) as ion exchange sites have been used as ionophores in the plasticized one- and two-layer membrane ion-selective electrodes. The LOD is reported to be 8.4 × 10^-5 M for mefenamic acid, and 5.1 × 10^-5 M for phenylanthranilic acid. The cations of basic dyes (crystal violet) are characterized by significant delocalization of the positive charge and polarizability. This may explain the better selectivity of the developed sensors. These sensors were used for the direct assay of mefenamic and N-phenylanthranilic acids in model solutions and applications studied in commercial pharmaceutical preparations.