Changing trends, clinicopathological characteristics, surgical treatment patterns, and prognosis of schistosomiasis-associated versus non-schistosomiasis-associated colorectal cancer: a large retrospective cohort study of 31 153 cases in Shanghai, China (2001-2021)

Nanxin Zheng; Hao Wang; Qing Yu; Chen Wang; Chen Guang Bai; An Fu Pan; Jianjun Jiang; Jian Lu; Si Min Dai; Zubing Mei; Wei Zhang; Xian Hua Gao

doi:10.1097/JS9.0000000000000293

Changing trends, clinicopathological characteristics, surgical treatment patterns, and prognosis of schistosomiasis-associated versus non-schistosomiasis-associated colorectal cancer: a large retrospective cohort study of 31 153 cases in Shanghai, China (2001-2021)

Int J Surg. 2023 Apr 1;109(4):772-784. doi: 10.1097/JS9.0000000000000293.

Authors

Nanxin Zheng^{1

2}, Hao Wang^{1

2}, Qing Yu³, Chen Wang^{1

2}, Chen Guang Bai⁴, An Fu Pan¹, Jianjun Jiang⁵, Jian Lu⁵, Si Min Dai³, Zubing Mei^{6

7}, Wei Zhang^{1

2}, Xian Hua Gao^{1

2}

Affiliations

¹ Department of Colorectal Surgery, Changhai Hospital, Naval Medical University.
² Hereditary Colorectal Cancer Center and Genetic Block Center of Familial Cancer, Changhai Hospital.
³ Department of Parasitic Disease, Shanghai Municipal Center for Disease Control and Prevention.
⁴ Department of Pathology, Changhai Hospital, Naval Medical University.
⁵ Department of Anorectal Surgery, Kongjiang Hospital, Yangpu District.
⁶ Department of Anorectal Surgery, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine.
⁷ Anorectal Disease Institute of Shuguang Hospital, Shanghai, People's Republic of China.

Abstract

Background: With the elimination of schistosomiasis in China, its role in the pathogenesis of colorectal cancer (CRC) has decreased. However, the trends, clinicopathological features, surgical treatment patterns, and prognosis of schistosomiasis-associated CRC (SACRC) versus non-schistosomiasis-associated CRC (NSACRC) in China remain unclear.

Materials and methods: The percentage trend of SACRC in CRC patients in China was analyzed using data retrieved from the Pathology Registry of Changhai Hospital (2001-2021). Clinicopathological characteristics, surgical treatment patterns, and prognosis-related parameters were compared between the two groups. Multivariate Cox regression analyses were performed for disease-free survival (DFS) and overall survival (OS).

Results: A total of 31 153 CRC cases were included, with 823 (2.6%) cases of SACRC and 30 330 (97.4%) cases of NSACRC. The average percentage of SACRC cases has decreased continuously from 3.8 to 1.7% (from 2001 to 2021). Compared with the NSACRC group, the SACRC group had more men, older age at diagnosis, lower BMI, fewer symptoms; higher rates of rectal cancer, comorbidities, KRAS mutation, multiple primary CRC and concomitant polyps; less lymph node metastasis, distant metastasis, vascular invasion, and tumor budding; less preoperative radiotherapy and preoperative chemotherapy; and more positive resection margins and postoperative targeted therapy. There were no significant differences between the two groups regarding laparoscopic surgery, palliative resection, extended radical resection, or ostomy. Moreover, the SACRC group had adverse DFS and similar OS compared with the NSACRC group. In multivariate analyses, schistosomiasis was not an independent predictor of DFS or OS.

Conclusion: The percentage of SACRC in CRC (2.6%) in our hospital was very low, and it decreased continuously over the last two decades, indicating that schistosomiasis is no longer an important risk factor for CRC in Shanghai, China. Patients with SACRC have distinct clinicopathological, molecular, and treatment-related features and survival rates similar to those with NSACRC.

MeSH terms

China / epidemiology
Colorectal Neoplasms* / pathology
Humans
Male
Neoplasm Staging
Prognosis
Rectal Neoplasms* / pathology
Rectal Neoplasms* / surgery
Retrospective Studies