Sustainable Green Synthesis of Pyrimidine Derivatives: Review on Multicomponent Synthesis, Catalysts and Techniques

Abstract

"The founder of green chemistry explains how chemicals manufacturing must change to support a sustainable future." In this review, Green chemistry is considered in the synthesis of heterocycles compounds containing Pyrimidine nuclei using different catalyzes, solvents, and techniques for the synthesis of pyrimidine derivatives that achieve sustainability. The mentioned fused heterocycles are classified according to the type of ring system. The yield of the target molecules reported in the review is given in the reaction's last step.

Keywords: Sustainable chemistry; green catalysts; green chemistry; microwave techniques; pyrimidine synthesis; solvent-free reactions; ultrasonic waves..