Novel functions of a retroposed gene

Izabela Makałowska; Magdalena Regina Kubiak

doi:10.1016/j.tig.2023.03.006

Novel functions of a retroposed gene

Trends Genet. 2023 Jun;39(6):439-441. doi: 10.1016/j.tig.2023.03.006. Epub 2023 Mar 28.

Authors

Izabela Makałowska¹, Magdalena Regina Kubiak²

Affiliations

¹ Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland. Electronic address: izabel@amu.edu.pl.
² Institute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.

PMID: 36997426
DOI: 10.1016/j.tig.2023.03.006

Abstract

Retroposed protein-coding genes are commonly considered to be nonfunctional duplicates. However, they often gain transcriptional capability and have important roles. Amici et al. recently identified novel functions of a retroposed gene. HAPSTR2, a retrocopy of HAPSTR1, encodes a protein that stabilizes the HAPSTR1 protein and functionally buffers its loss.

Keywords: HAPSTR2; retrocopy.

MeSH terms

Evolution, Molecular*
Retroelements* / genetics

Substances

Retroelements