Research progress on the role of RNA N6-methyladenosine methylation in HCV infection

Yiyang Ge; Shi Tang; Tian Xia; Chunwei Shi

doi:10.1016/j.virol.2023.03.007

Research progress on the role of RNA N⁶-methyladenosine methylation in HCV infection

Virology. 2023 May:582:35-42. doi: 10.1016/j.virol.2023.03.007. Epub 2023 Mar 24.

Authors

Yiyang Ge¹, Shi Tang¹, Tian Xia², Chunwei Shi³

Affiliations

¹ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
² Department of Surgery, Wuhan Third Hospital, Wuhan, PR China. Electronic address: 511636443@qq.com.
³ Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China. Electronic address: chunweishi@hust.edu.cn.

PMID: 36996690
DOI: 10.1016/j.virol.2023.03.007

Abstract

Hepatitis C virus (HCV) is a positive-stranded RNA virus causing chronic liver diseases. The chemical modification of RNA is a research hotspot in related fields in recent years, including the methylation and acetylation of adenine, guanine, cytosine and other bases, among which methylation is the most important modification form. m⁶A (N⁶-methyladenosine), as the most abundant RNA modification form, plays an important role in HCV virus infection by modifying viral RNA and cell transcripts. This review aims to summarize the current knowledge on the roles of m⁶A modification in HCV infection, and discuss the research prospect.

Keywords: HCV infection; N(6)-methyladenosine modification; RNA methylation Modification.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Hepacivirus / genetics
Hepacivirus / metabolism
Hepatitis C* / genetics
Humans
Methylation
RNA* / metabolism
RNA, Viral / genetics
RNA, Viral / metabolism

Substances

RNA
N-methyladenosine
RNA, Viral