Bioluminescence tomography system for in vivo irradiation guidance

Zijian Deng; Xiangkun Xu; Iulian Iordachita; Hamid Dehghani; Bin Zhang; John W Wong; Ken Kang-Hsin Wang

doi:10.1364/OTS.2022.OTu2D.3

Bioluminescence tomography system for in vivo irradiation guidance

Biomed Opt. 2022 Apr:2022:OTu2D.3. doi: 10.1364/OTS.2022.OTu2D.3.

Authors

Zijian Deng^{1

2}, Xiangkun Xu^{1

2}, Iulian Iordachita³, Hamid Dehghani⁴, Bin Zhang⁵, John W Wong¹, Ken Kang-Hsin Wang^{1

2}

Affiliations

¹ Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, Maryland 21287, USA.
² Biomedical Imaging and Radiation Technology Laboratory, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
³ Laboratory for Computational Sensing and Robotics, Johns Hopkins University, Baltimore, Maryland 21218, USA.
⁴ School of Computer Science, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
⁵ School of Biomedical Engineering, Dalian University of Technology, Dalian, Liaoning 116024, China.

Abstract

We constructed a bioluminescence tomography(BLT) to localize soft tissue targets for preclinical radiotherapy study. With the threshold and margin designed for target volume, BLT can provide opportunity to perform conformal irradiation to malignancy.

Abstract

Grants and funding