Acinetobacter Baumannii Phages: Past, Present and Future

Qihang Tu; Mingfang Pu; Yahao Li; Yuer Wang; Maochen Li; Lihua Song; Mengzhe Li; Xiaoping An; Huahao Fan; Yigang Tong

doi:10.3390/v15030673

Acinetobacter Baumannii Phages: Past, Present and Future

Viruses. 2023 Mar 3;15(3):673. doi: 10.3390/v15030673.

Authors

Qihang Tu¹, Mingfang Pu¹, Yahao Li², Yuer Wang¹, Maochen Li¹, Lihua Song¹, Mengzhe Li¹, Xiaoping An¹, Huahao Fan¹, Yigang Tong^{1

2}

Affiliations

¹ College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
² Beijing Advanced Innovation Center for Soft Matter Science and Engineering (BAIC-SM), Beijing University of Chemical Technology, Beijing 100029, China.

Abstract

Acinetobacter baumannii (A. baumannii) is one of the most common clinical pathogens and a typical multi-drug resistant (MDR) bacterium. With the increase of drug-resistant A. baumannii infections, it is urgent to find some new treatment strategies, such as phage therapy. In this paper, we described the different drug resistances of A. baumannii and some basic properties of A. baumannii phages, analyzed the interaction between phages and their hosts, and focused on A. baumannii phage therapies. Finally, we discussed the chance and challenge of phage therapy. This paper aims to provide a more comprehensive understanding of A. baumannii phages and theoretical support for the clinical application of A. baumannii phages.

Keywords: Acinetobacter baumannii; bacteriophage; multi-drug resistance; phage therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acinetobacter baumannii*
Anti-Bacterial Agents
Bacteriophages*

Substances

Anti-Bacterial Agents

Grants and funding

This research was supported by the National Key Research and Development Program of China (grant no. 2019YFC1200502, 2020YFA0712102, BWS21J025, 20SWAQK22), National Natural Science Foundation of China (grant no. 82151224), Fundamental Research Funds for Central Universities (grant no. BUCTZY2022), and H&H Global Research and Technology Center (grant no. H2021028).