A Self-Propagating c-Met-SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

Xinmei Huang; Shenghua Zhang; Jingshu Tang; Tian Tian; Yilin Pan; Lina Wu; Jingxuan Zhang; Yang Liu; Jing Huang; Hui Dai; Weiyan Xu; Youhui Zhang; Jinfeng Chen; Mengshu Cao; Liang Zhang; Xiaoyan Qiu

doi:10.1158/0008-5472.CAN-22-2733

A Self-Propagating c-Met-SOX2 Axis Drives Cancer-Derived IgG Signaling That Promotes Lung Cancer Cell Stemness

Cancer Res. 2023 Jun 2;83(11):1866-1882. doi: 10.1158/0008-5472.CAN-22-2733.

Authors

Xinmei Huang^{1

2

3}, Shenghua Zhang^{1

2}, Jingshu Tang^{1

2}, Tian Tian^{4

5}, Yilin Pan^{4

5}, Lina Wu⁶, Jingxuan Zhang^{1

2}, Yang Liu^{1

2}, Jing Huang^{1

2}, Hui Dai^{1

2}, Weiyan Xu^{1

2}, Youhui Zhang⁷, Jinfeng Chen⁸, Mengshu Cao³, Liang Zhang^{4

5

9}, Xiaoyan Qiu^{1

2}

Affiliations

¹ Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing, China.
² NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
³ Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
⁴ Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong, China.
⁵ City University of Hong Kong Shenzhen Research Institute, Shenzhen, Guangdong, China.
⁶ Central Laboratory, Key Laboratory of Carcinogenesis and Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.
⁷ Department of Immunology, Cancer Institute & Hospital, Chinese Academy of Medical Science, Beijing, China.
⁸ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China.
⁹ Department of Precision Diagnostic and Therapeutic Technology, City University of Hong Kong Futian Research Institute, Shenzhen, Guangdong, China.

PMID: 36989345
DOI: 10.1158/0008-5472.CAN-22-2733

Abstract

Sialylated cancer IgG activates c-Met-SOX2 signaling to promote stemness properties in cancer cells and can be targeted to suppress tumor growth.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Humans
Immunoglobulin G
Lung Neoplasms* / genetics
Lung Neoplasms* / pathology
Neoplastic Stem Cells / pathology
SOXB1 Transcription Factors / genetics
SOXB1 Transcription Factors / metabolism
Signal Transduction

Substances

Immunoglobulin G
SOXB1 Transcription Factors
SOX2 protein, human