Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose

Drugs R D. 2023 Jun;23(2):93-98. doi: 10.1007/s40268-023-00415-9. Epub 2023 Mar 29.

Abstract

Background and objective: Metamizole is a non-opioid ampyrone sulfonate compound with potent analgesic, antipyretic, and spasmolytic effects. Agranulocytosis is a rare life-threatening complication of metamizole.

Case: Here, we present the case of a 62-year-old patient who developed agranulocytosis as well as hemolysis after a single administration of metamizole.

Conclusion: This case illustrates the inherent allergic potential of metamizole and its effects on different hematopoietic cell types.

Publication types

  • Case Reports

MeSH terms

  • Agranulocytosis* / chemically induced
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Dipyrone / adverse effects
  • Hemolysis
  • Humans
  • Middle Aged
  • Neutropenia*

Substances

  • Dipyrone
  • Anti-Inflammatory Agents, Non-Steroidal