Background: Inaccurate test results may be a reason why vitamin D deficiency is seen as a common problem worldwide. Interferences from the sample matrix during testing are the most important factors in measurement errors. In this study, the relationship between triglycerides and total cholesterol levels and vitamin D levels in Turkey was investigated.
Methods: The 25-hydroxyvitamin D test results and lipid test results studied in Turkey in 2021 were compared. Data were obtained from the Ministry of Health National Health Database. Simultaneously, 25-hydroxyvitamin D, triglyceride, and total cholesterol levels were studied, and 1,135,644 test results were taken as the basis.
Results: In the group of patients with total cholesterol levels between 0-10.33 mmol/L, the proportion of patients below 20 mg/L ranged from 56.8% to 61.8%. In the patient group with cholesterol between 10.36-259 mmol/L, the rate of patients with less than 20 mg/L was between 70.8-100%, while the rate of patients with cholesterol above 100 mg/L was 0%. The mean 25-hydroxyvitamin D level was 20.1 mg/L in the patient group with a total cholesterol level between 0-10.33 mmol/L, and 16 mg/L in the patient group with a cholesterol level above 10.36 mmol/L. The mean 25-hydroxyvitamin D level was 20.11 mg/L in the patient group with triglycerides 0-10.16 mmol/L, and the 25-hydroxyvitamin D level was 12.28 mg/L in the patient group with triglycerides 10.17-113 mmol/L. The proportion of patients with vitamin D levels above 100 mg/L was found to be 0% in the group of patients with triglycerides above 10.17-113 mmol/L.
Conclusions: According to this study, there is a risk of toxicity when administering vitamin D therapy in patients with high cholesterol and triglycerides levels. This study is the first of this size in the literature. High triglycerides and cholesterol levels can cause inaccurate measurement of vitamin D levels, so care should be taken when evaluating these tests.
Uvod: Netačni rezultati testova mogu biti razlog zašto se nedostatak vitamina D smatra uobičajenim problemom širom sveta. Interferencije iz matrice uzorka tokom testiranja su najvažniji faktori grešaka u merenju. U ovoj studiji istražen je odnos između nivoa triglicerida i ukupnog holesterola i nivoa vitamina D u Turskoj.
Metode: Upoređeni su rezultati testa 25-hidroksivitamina D i rezultati testa lipida koji su proučavani u Turskoj 2021. godine. Podaci su dobijeni iz Nacionalne zdravstvene baze podataka Ministarstva zdravlja. Istovremeno su proučavani nivoi 25-hidroksivitamina D, triglicerida i ukupnog holesterola, a za osnovu su uzeta 1.135.644 rezultata testova.
Rezultati: U grupi pacijenata sa nivoom ukupnog holesterola između 0-10,33 mmol/L, udeo pacijenata ispod 20 mg/L kretao se od 56,8% do 61,8%. U grupi pacijenata sa holesterolom između 10,36-259 mmol/L, stopa pacijenata sa manje od 20 mg/L bila je između 70,8-100%, dok je stopa pacijenata sa holesterolom iznad 100 mg/L bila 0%. Prosečan nivo 25-hidroksivitamina D bio je 20,1 mg/L u grupi pacijenata sa nivoom ukupnog holesterola između 0-10,33 mmol/L i 16 mg/L u grupi pacijenata sa nivoom holesterola iznad 10,36 mmol/L. Prosečan nivo 25-hidroksi vitamina D bio je 20,11 mg/L u grupi pacijenata sa trigliceridima 0-10,16 mmol/L, a nivo 25-hidroksivitamina D je bio 12,28 mg/L u grupi pacijenata sa trigliceridima 10,17-113 mmol. Utvrđeno je da je procenat pacijenata sa nivoom vitamina D iznad 100 mg/L 0% u grupi pacijenata sa trigliceridima iznad 10,17-113 mmol/L.
Zaključak: Prema ovoj studiji, postoji rizik od toksičnosti pri primeni terapije vitaminom D kod pacijenata sa visokim nivoom holesterola i triglicerida. Ova studija je prva ove veličine u literaturi. Visoki nivoi triglicerida i holesterola mogu uzrokovati netačno merenje nivoa vitamina D, tako da treba biti oprezan prilikom procene ovih testova.
Keywords: 25-OH vitamin D; big data; cholesterol; triglycerides; vitamin D deficiency.
2023 Murat Çağlayan, Ataman Gonel, Tugba Songul Tat, Osman Celik, Fidanci Ali Aykut, Ayvali Mustafa Okan, Ulgu Mustafa Mahir, Naim Ata, Suayip Birinci, published by CEON/CEES.