Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants

Anna Parra-Llorca; Alejandro Pinilla-Gonzlez; Laura Torrejón-Rodríguez; Inmaculada Lara-Cantón; Julia Kuligowski; María Carmen Collado; María Gormaz; Marta Aguar; Máximo Vento; Eva Serna; María Cernada

doi:10.3390/children10030602

Effects of Sepsis on Immune Response, Microbiome and Oxidative Metabolism in Preterm Infants

Children (Basel). 2023 Mar 22;10(3):602. doi: 10.3390/children10030602.

Authors

Anna Parra-Llorca^{1

2}, Alejandro Pinilla-Gonzlez^{1

2}, Laura Torrejón-Rodríguez^{1

2}, Inmaculada Lara-Cantón^{1

2}, Julia Kuligowski², María Carmen Collado³, María Gormaz^{1

2}, Marta Aguar^{1

2}, Máximo Vento^{1

2}, Eva Serna⁴, María Cernada^{1

2}

Affiliations

¹ Division of Neonatology, University and Polytechnic Hospital La Fe (HULAFE), 46026 Valencia, Spain.
² Neonatal Research Group, Health Research Institute La Fe (IISLAFE), 46026 Valencia, Spain.
³ Department of Biotechnology, Institute of Agrochemistry and Food Technology, National Research Council (IATA-CSIC), 46980 Valencia, Spain.
⁴ Department of Physiology, University of Valencia, 46010 Valencia, Spain.

Abstract

This is a narrative review about the mechanisms involved in bacterial sepsis in preterm infants, which is an illness with a high incidence, morbidity, and mortality. The role of the innate immune response and its relationship with oxidative stress in the pathogenesis are described as well as their potential implementation as early biomarkers. Moreover, we address the impact that all the mechanisms triggered by sepsis have on the dysbiosis and the changes on neonatal microbiota.

Keywords: immune response; microbiome; oxidative stress; preterm; sepsis.

Publication types

Review

Grants and funding

This research received no external funding.