Recent advances in metabolic engineering of microorganisms for the production of monomeric C3 and C4 chemical compounds

Shengfang Zhou; Yingli Zhang; Zhiwen Wei; Sunghoon Park

doi:10.1016/j.biortech.2023.128973

Recent advances in metabolic engineering of microorganisms for the production of monomeric C3 and C4 chemical compounds

Bioresour Technol. 2023 Jun:377:128973. doi: 10.1016/j.biortech.2023.128973. Epub 2023 Mar 25.

Authors

Shengfang Zhou¹, Yingli Zhang¹, Zhiwen Wei¹, Sunghoon Park²

Affiliations

¹ The Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province, School of Life Sciences, Jiangsu Normal University, Xuzhou, China.
² School of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea. Electronic address: parksh@unist.ac.kr.

PMID: 36972803
DOI: 10.1016/j.biortech.2023.128973

Abstract

Bio-based C3 and C4 bi-functional chemicals are useful monomers in biopolymer production. This review describes recent progresses in the biosynthesis of four such monomers as a hydroxy-carboxylic acid (3-hydroxypropionic acid), a dicarboxylic acid (succinic acid), and two diols (1,3-propanediol and 1,4-butanediol). The use of cheap carbon sources and the development of strains and processes for better product titer, rate and yield are presented. Challenges and future perspectives for (more) economical commercial production of these chemicals are also briefly discussed.

Keywords: 1,3-Propanediol; 1,4-Butanediol; 3-Hydroxypropionic acid; Metabolic engineering; Succinic acid.

Publication types

Review

MeSH terms

Dicarboxylic Acids* / metabolism
Metabolic Engineering*
Succinic Acid / metabolism

Substances

Dicarboxylic Acids
Succinic Acid