Studies directed toward introduction of N6-isopentenyladenosine and its 2-methylthio analogue into oligoribonucleotides

P Swiderski; P Dembek; W S Antkowiak; E Biała; R W Adamiak

Studies directed toward introduction of N6-isopentenyladenosine and its 2-methylthio analogue into oligoribonucleotides

Nucleic Acids Symp Ser. 1987:(18):105-8.

Authors

P Swiderski¹, P Dembek, W S Antkowiak, E Biała, R W Adamiak

Affiliation

¹ Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.

PMID: 3697108

Abstract

A new efficient route of i6A and ms2i6A synthesis, especially useful for the preparation of i6A-containing oligoribonucleotides eg. Api6A has been proposed. The method is based on aminolysis of a 6-methylsulfonylpurine system formed by oxidation of its 6-methylthio precursor.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine* / analogs & derivatives*
Indicators and Reagents
Isopentenyladenosine* / analogs & derivatives*
Oligoribonucleotides / chemical synthesis*

Substances

Indicators and Reagents
Oligoribonucleotides
2-methylthio-N-6-isopentenyladenosine
Isopentenyladenosine
Adenosine