Nanotechnological strategies to increase the oxygen content of the tumor

Junjie Zhang; Kaiyuan Tang; Runqi Fang; Jiaming Liu; Ming Liu; Jiayi Ma; Hui Wang; Meng Ding; Xiaoxiao Wang; Yanni Song; Dongliang Yang

doi:10.3389/fphar.2023.1140362

Nanotechnological strategies to increase the oxygen content of the tumor

Front Pharmacol. 2023 Mar 9:14:1140362. doi: 10.3389/fphar.2023.1140362. eCollection 2023.

Authors

Junjie Zhang¹, Kaiyuan Tang¹, Runqi Fang¹, Jiaming Liu¹, Ming Liu¹, Jiayi Ma¹, Hui Wang¹, Meng Ding², Xiaoxiao Wang³, Yanni Song⁴, Dongliang Yang⁴

Affiliations

¹ School of Fundamental Sciences, Bengbu Medical College, Bengbu, China.
² Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, China.
³ Biochemical Engineering Research Center, School of Chemistry and Chemical Engineering, Anhui University of Technology, Ma'anshan, China.
⁴ Key Laboratory of Flexible Electronics (KLOFE), Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing, China.

Abstract

Hypoxia is a negative prognostic indicator of solid tumors, which not only changes the survival state of tumors and increases their invasiveness but also remarkably reduces the sensitivity of tumors to treatments such as radiotherapy, chemotherapy and photodynamic therapy. Thus, developing therapeutic strategies to alleviate tumor hypoxia has recently been considered an extremely valuable target in oncology. In this review, nanotechnological strategies to elevate oxygen levels in tumor therapy in recent years are summarized, including (I) improving the hypoxic tumor microenvironment, (II) oxygen delivery to hypoxic tumors, and (III) oxygen generation in hypoxic tumors. Finally, the challenges and prospects of these nanotechnological strategies for alleviating tumor hypoxia are presented.

Keywords: cancer treatment; hypoxia; nanomaterial; nanozyme; tumor microenvironment.

Publication types

Review

Grants and funding

This work was supported by the Department of Education of Anhui Province (KJ2021A0732), the National College Students’ innovation and entrepreneurship training program (202210367075), the Science and Technology Innovation Guidance Project of Bengbu City (20220127), the NNSF of China (52103166) and the NSF of Jiangsu Province (BK20200710).