Beneficial insights into postbiotics against colorectal cancer

Dingka Song; Xiuli Wang; Yongjing Ma; Ning-Ning Liu; Hui Wang

doi:10.3389/fnut.2023.1111872

Beneficial insights into postbiotics against colorectal cancer

Front Nutr. 2023 Mar 10:10:1111872. doi: 10.3389/fnut.2023.1111872. eCollection 2023.

Authors

Dingka Song¹, Xiuli Wang¹, Yongjing Ma¹, Ning-Ning Liu¹, Hui Wang¹

Affiliation

¹ State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Colorectal cancer (CRC) is one of the most prevalent and life-threatening cancer types with limited therapeutic options worldwide. Gut microbiota has been recognized as the pivotal determinant in maintaining gastrointestinal (GI) tract homeostasis, while dysbiosis of gut microbiota contributes to CRC development. Recently, the beneficial role of postbiotics, a new concept in describing microorganism derived substances, in CRC has been uncovered by various studies. However, a comprehensive characterization of the molecular identity, mechanism of action, or routes of administration of postbiotics, particularly their role in CRC, is still lacking. In this review, we outline the current state of research toward the beneficial effects of gut microbiota derived postbiotics against CRC, which will represent the key elements of future precision-medicine approaches in the development of novel therapeutic strategies targeting gut microbiota to improve treatment outcomes in CRC.

Keywords: CRC; gut microbiota; immune regulation; nutritional intervention; postbiotics.

Publication types

Review

Grants and funding

This work was supported by MOST Key R&D Program of China (2022YFC2304703 and 2020YFA0907200), National Natural Science Foundation of China (31900129, 32270202, 82030099, and 32200749), Natural Science Foundation of Shanghai (22ZR1435900), and Innovative research team of high-level local universities in Shanghai.