Pocket ACEs: Discovering new function within an old player

Matthew Leong; Xiaomo Li; Manita Chaum

doi:10.3389/fphys.2023.1151908

Pocket ACEs: Discovering new function within an old player

Front Physiol. 2023 Mar 10:14:1151908. doi: 10.3389/fphys.2023.1151908. eCollection 2023.

Authors

Matthew Leong¹, Xiaomo Li¹, Manita Chaum¹

Affiliation

¹ Cedars Sinai Medical Center, Los Angeles, CA, United States.

Abstract

Angiotensin-converting enzyme (ACE) is canonically known for its role in the renin-angiotensin system (RAS) where its conversion of angiotensin I (Ang I) to the bioactive peptide angiotensin II (Ang II) helps to regulate blood pressure, electrolyte, and volume homeostasis. Further studies on ACE have shown that its enzymatic activity is relatively non-specific and functions outside of the RAS axis. Of the multiple systems it has been implicated in, ACE has been found to play an important role in the development and modulation of hematopoiesis and the immune system, both through the RAS and independently of the RAS axis.

Keywords: ACE; RAS; anti inflammation; hemato- and immunological effects; immunmodulation; macrophage; neutrophil.

Publication types

Review