Metabolic regulation of dendritic cell activation and immune function during inflammation

Lili Wu; Ziqi Yan; Yiyang Jiang; Yingyi Chen; Juan Du; Lijia Guo; Junji Xu; Zhenhua Luo; Yi Liu

doi:10.3389/fimmu.2023.1140749

Metabolic regulation of dendritic cell activation and immune function during inflammation

Front Immunol. 2023 Mar 8:14:1140749. doi: 10.3389/fimmu.2023.1140749. eCollection 2023.

Authors

Lili Wu^{1

2}, Ziqi Yan^{1

2}, Yiyang Jiang^{1

2}, Yingyi Chen^{1

2}, Juan Du^{1

2}, Lijia Guo³, Junji Xu^{1

2}, Zhenhua Luo^{1

2}, Yi Liu^{1

2}

Affiliations

¹ Laboratory of Tissue Regeneration and Immunology and Department of Periodontics, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing, China.
² Immunology Research Center for Oral and Systemic Health, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
³ Department of Orthodontics School of Stomatology, Capital Medical University, Beijing, China.

Abstract

Dendritic cells (DCs) are antigen-presenting cells that bridge innate and adaptive immune responses. Multiple cell types, including DCs, rely on cellular metabolism to determine their fate. DCs substantially alter cellular metabolic pathways during activation, such as oxidative phosphorylation, glycolysis, fatty acid and amino acid metabolism, which have crucial implications for their functionality. In this review, we summarize and discuss recent progress in DC metabolic studies, focusing on how metabolic reprogramming influences DC activation and functionality and the potential metabolic differences among DC subsets. Improving the understanding of the relationship between DC biology and metabolic regulation may provide promising therapeutic targets for immune-mediated inflammatory diseases.

Keywords: cellular metabolism; dendritic cells (DC); glycolysis; inflammation; metabolic reprogramming.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Dendritic Cells*
Glycolysis*
Humans
Immunity
Inflammation / metabolism
Oxidative Phosphorylation

Grants and funding

This work was supported by grants from the National Nature Science Foundation of China (81991504 and 81974149 to YL, 82122015 to JX), the Beijing Stomatological Hospital, Capital Medical University Young Scientist Program (YSP20200904 to LJ), the Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX202121 to YL), Beijing Municipal Administration of Hospitals’ Ascent Plan (DFL20181501 to YL), the Innovation research team project of Beijing Stomatological Hospital, Capital Medical University (CXTD202202 to YL).