Platelet, a key regulator of innate and adaptive immunity

Cheng Yan; Haojie Wu; Xianchun Fang; Junji He; Feng Zhu

doi:10.3389/fmed.2023.1074878

Platelet, a key regulator of innate and adaptive immunity

Front Med (Lausanne). 2023 Mar 10:10:1074878. doi: 10.3389/fmed.2023.1074878. eCollection 2023.

Authors

Cheng Yan¹, Haojie Wu², Xianchun Fang¹, Junji He¹, Feng Zhu¹

Affiliations

¹ Department of Blood Transfusion, Nanjing Jiangning Hospital, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
² Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Abstract

Platelets, anucleate blood components, represent the major cell type involved in the regulation of hemostasis and thrombosis. In addition to performing haemostatic roles, platelets can influence both innate and adaptive immune responses. In this review, we summarize the development of platelets and their functions in hemostasis. We also discuss the interactions between platelet products and innate or adaptive immune cells, including neutrophils, monocytes, macrophages, T cells, B cells and dendritic cells. Activated platelets and released molecules regulate the differentiation and function of these cells via platelet-derived receptors or secreting molecules. Platelets have dual effects on nearly all immune cells. Understanding the exact mechanisms underlying these effects will enable further application of platelet transfusion.

Keywords: B cell; T cell; dendritic cell; macrophage; monocyte; platelet.

Publication types

Review