A swarm of semi-classical quantum mechanics/molecular mechanics molecular-dynamics simulations where OM2/MNDO is combined with the Gromacs program for consideration of explicit water is performed, solving the time-dependent Schrödinger equation in each step of the trajectories together with the Tully's fewest switches algorithm. Within this stochastic treatment, time dependent probabilities of the three lowest electronic states are determined. The fact that nucleobases are quickly deactivated is confirmed in the cytosine case where our best lifetime estimation is τ1=0.82 ps for the model with 100 water molecules with the SPCE force field and a time step of 0.1 fs. Lifetimes of the remaining molecules are visibly longer: 5-azacytosine, 2,4-diamino-1,3,5-triazine (DT), and 2,4,6-triamino-1,3,5-triazine (TT) molecules have an S1 → S0 de-excitation time of slightly above 10 ps. The lifetimes of the triazine family increases with the increasing number of exocyclic amino groups, that is, s-triazine < 2-amino-1,3,5-triazine < DT < TT. This can be explained by a higher mobility of the carbon-bonded hydrogen atoms in comparison with heavier amino groups since their movement is slowed down due to a substantially higher mass than hydrogen atoms, which can easier reach the out-of-plane positions required in the conical intersection structures. Moreover, bulkier NH2 ligands suffer due to greater friction caused by the surrounding water environment. These mechanical aspects caused a change in the explored lifetime dependences in comparison with our previous gas-phase study.