A new amide from the fruiting bodies of Tricholoma bakamatsutake

Magn Reson Chem. 2023 Jul;61(7):443-447. doi: 10.1002/mrc.5348. Epub 2023 Apr 13.

Abstract

A new amide tricholomine C was isolated from the dried fruiting bodies of Tricholoma bakamatsutake. Its structure was identified by a combination of nuclear magnetic resonance spectroscopic analysis and electronic circular dichroism (ECD) calculations. The ethyl alcohol crude extract and tricholomines A-C from T. bakamatsutake were evaluated for neuroprotective activities. Of these substances, the crude extract showed weak neurite outgrowth-promoting activity in rat pheochromocytoma (PC12) cells, as well as weak inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE).

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase* / analysis
  • Amides / analysis
  • Amides / pharmacology
  • Animals
  • Butyrylcholinesterase* / analysis
  • Complex Mixtures / analysis
  • Fruiting Bodies, Fungal / chemistry
  • Rats

Substances

  • Butyrylcholinesterase
  • Acetylcholinesterase
  • Amides
  • Complex Mixtures

Supplementary concepts

  • Tricholoma bakamatsutake