EEG coherences of the fronto-limbic circuit between patients with major depressive disorder and healthy controls

Abstract

Background: Imaging studies found that patients with major depressive disorder (MDD) showed abnormal functional connectivity in the fronto-limbic circuit, including the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and limbic system (amygdala). This study used electroencephalography (EEG) coherence as an indicator of functional connectivity in the fronto-limbic circuit and examined the group differences between the MDD group and healthy controls (HC group), and the associations between EEG coherence and depressive symptoms.

Methods: 125 and 132 participants in the MDD and HC groups have measured the symptoms of depression and anxiety, and delta, theta, alpha, and beta1-beta4 EEG coherences in the fronto-limbic circuit and examined the differences between the two groups, and the associations between the EEG coherence and depressive symptoms were examined.

Results: Lower theta, alpha, beta1, beta3, and beta4 coherence in the fronto-limbic circuit and higher beta2 coherence between the PFC and limbic system in the MDD group than in the HC group. Negative correlations between delta, theta, beta1, beta3, and beta4 coherence and total depression, cognitive depression, and somatic depression; positive correlations between beta2 coherences in the PFC and limbic system, and total depression and cognitive depression scores in the MDD group.

Limitations: Whether low EEG coherence in the fronto-limbic circuit is applicable to other subtypes of MDD requires further study.

Conclusions: Low EEG coherences in the fronto-limbic circuit were related to depressive symptoms, and increased functional connectivity in the fronto-limbic circuit can be applied by neurofeedback in future studies.

Keywords: Coherence; Depressive symptoms; Electroencephalography; Fronto-limbic circuit; Functional connectivity; Major depressive disorder.