Association between sarcopenia and kidney stones in United States adult population between 2011 and 2018

Yifan Zhang; Changxiu Tian; Yidi Wang; Houliang Zhang; Jinliang Ni; Wei Song; Huajuan Shi; Tao Zhang; Changbao Xu; Keyi Wang; Bo Peng

doi:10.3389/fnut.2023.1123588

Association between sarcopenia and kidney stones in United States adult population between 2011 and 2018

Front Nutr. 2023 Mar 6:10:1123588. doi: 10.3389/fnut.2023.1123588. eCollection 2023.

Authors

Yifan Zhang¹, Changxiu Tian¹, Yidi Wang¹, Houliang Zhang¹, Jinliang Ni¹, Wei Song¹, Huajuan Shi², Tao Zhang², Changbao Xu³, Keyi Wang¹, Bo Peng^{1

2}

Affiliations

¹ Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
² Department of Urology, Shanghai Putuo District People's Hospital, Tongji University, Shanghai, China.
³ Department of Urology, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Abstract

Purpose: To investigate the relationship between kidney stones and sarcopenia in United States adult population between 2011 and 2018.

Materials and methods: We conducted a cross-section study based on the National Health and Nutrition Examination Survey (NHANES) including 39,156 individuals. Sarcopenia was assessed by the sarcopenia index. Association between kidney stones and sarcopenia verified by multiple logistic regression analysis and dose-response curves analysis using restricted cubic spline (RCS) regression. Meanwhile, propensity score matching (PSM) was performed to exclude the effect of confounding variables.

Results: There were 9,472 participants in the study by our accurate enrollment screening process. The odds of kidney stones decreased significantly with the increase of sarcopenia index. Logistic regression analysis showed that sarcopenia expressed significant differences in the participants which suffered kidney stone before PSM (p < 0.001). In model 4, adjusting all relevant covariates shown that adjusted odds ratio (aOR) of the 95% confidence intervals for kidney stones in all participants, age <39 years and age ≥40 years, were, respectively, 1.286 (1.006-1,643), 1.697 (1.065-2.702), and 0.965 (0.700-1.330) for sarcopenia, and p values were 0.044, 0.026, and 0.827. After performing PSM, the aOR of the 95% in modal 4 for kidney stones in all participants and age <40 year were 2.365 (1.598-3.500) and 6.793 (2.619-17.6180), respectively (p < 0.01), and especially the aOR in participants (age ≥40) was 1.771(1.138-2.757) with p value being 0.011.

Conclusion: Sarcopenia was positively related to the potential risk of kidney stones in the United States adult population.

Keywords: NHANES; cross-section study; kidney stones; sarcopenia; sarcopenia index.