Perspectives on Prediabetes and Aging

Mohammed E Al-Sofiani; Alanood Asiri; Sarah Alajmi; Walid Alkeridy

doi:10.1016/j.ecl.2022.10.011

Perspectives on Prediabetes and Aging

Endocrinol Metab Clin North Am. 2023 Jun;52(2):377-388. doi: 10.1016/j.ecl.2022.10.011. Epub 2023 Feb 16.

Authors

Mohammed E Al-Sofiani¹, Alanood Asiri², Sarah Alajmi², Walid Alkeridy³

Affiliations

¹ Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Central Region, 12372, Saudi Arabia; Division of Endocrinology, Diabetes & Metabolism, The Johns Hopkins University, 1830 East Monument Street, Baltimore, MD 21287, USA. Electronic address: malsofiani@ksu.edu.sa.
² Division of Endocrinology, Department of Internal Medicine, College of Medicine, King Saud University, Riyadh, Central Region, 12372, Saudi Arabia.
³ Department of Medicine, King Saud University, College of Medicine, Riyadh, Central Region, 12372, Saudi Arabia.

PMID: 36948785
DOI: 10.1016/j.ecl.2022.10.011

Abstract

Diabetes prevention programs (DPPs) have been shown to effectively delay, and sometimes prevent, the progression from prediabetes to diabetes; however, labeling someone with prediabetes comes with potential negative psychological, financial, and self-perception consequences. Many older adults with prediabetes nowadays have a relatively "low-risk" form of prediabetes that rarely progresses to diabetes and may regress to normoglycemia. In this article, we review the impact of aging on glucose metabolism and provide a holistic approach to cases of prediabetes in older adults that maximizes the benefit-risk balance of interventions aimed at addressing prediabetes.

Keywords: Aging; Impaired fasting glucose; Impaired glucose tolerance; Older adults; Prediabetes.

Publication types

Review

MeSH terms

Aged
Aging
Blood Glucose / metabolism
Diabetes Mellitus*
Humans
Prediabetic State* / therapy
Risk Assessment

Substances

Blood Glucose