Newer Glucose-Lowering Therapies in Older Adults with Type 2 Diabetes

Endocrinol Metab Clin North Am. 2023 Jun;52(2):355-375. doi: 10.1016/j.ecl.2022.10.010. Epub 2023 Feb 20.

Abstract

Diabetes is prevalent in older adults and older adults with diabetes are more likely to have multiple comorbidities. It is, therefore, important to personalize diabetes management in this group. Newer glucose-lowering drugs, including dipeptidyl peptidase-4 inhibitors, sodium-glucose cotransporter 2 inhibitors, and glucagon-like peptide-1 receptor agonists can be safely used in older patients and are preferred choices in many cases due to their safety, efficacy, and low risk of hypoglycemia.

Keywords: DPP-4 inhibitors; Diabetes subtypes; GLP-1 receptor agonists; Older adults; Precision medicine; SGLT-2 inhibitors; Tirzepatide; Type 2 diabetes.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Diabetes Mellitus, Type 2* / drug therapy
  • Dipeptidyl-Peptidase IV Inhibitors* / adverse effects
  • Glucose / therapeutic use
  • Humans
  • Hypoglycemic Agents / adverse effects
  • Sodium-Glucose Transporter 2 Inhibitors* / therapeutic use

Substances

  • Hypoglycemic Agents
  • Glucose
  • Sodium-Glucose Transporter 2 Inhibitors
  • Dipeptidyl-Peptidase IV Inhibitors