The role of insulin-like growth factor-1 in bone remodeling: A review

Jiayuan Fang; Xunming Zhang; Xi Chen; Zhaoguo Wang; Shuo Zheng; Yunyun Cheng; Songcai Liu; Linlin Hao

doi:10.1016/j.ijbiomac.2023.124125

The role of insulin-like growth factor-1 in bone remodeling: A review

Int J Biol Macromol. 2023 May 31:238:124125. doi: 10.1016/j.ijbiomac.2023.124125. Epub 2023 Mar 21.

Authors

Jiayuan Fang¹, Xunming Zhang¹, Xi Chen¹, Zhaoguo Wang¹, Shuo Zheng¹, Yunyun Cheng², Songcai Liu¹, Linlin Hao³

Affiliations

¹ College of Animal Science, Jilin University, Changchun 130062, China.
² College of Public Health, Jilin University, Changchun 130061, China.
³ College of Animal Science, Jilin University, Changchun 130062, China. Electronic address: haolinlin@jlu.edu.cn.

PMID: 36948334
DOI: 10.1016/j.ijbiomac.2023.124125

Abstract

Insulin-like growth factor (IGF)-1 is a polypeptide hormone with vital biological functions in bone cells. The abnormal expression of IGF-1 has a serious effect on bone growth, particularly bone remodeling. Evidence from animal models and human disease suggested that both IGF-1 deficiency and excess cause changes in bone remodeling equilibrium, resulting in profound alterations in bone mass and development. Here, we first introduced the functions and mechanisms of the members of IGFs in bone. Subsequently, the critical role of IGF-1 in the process of bone remodeling were emphasized from the aspects of bone resorption and bone formation respectively. This review explains the mechanism of IGF-1 in maintaining bone mass and bone homeostasis to a certain extent and provides a theoretical basis for further research.

Keywords: Bone formation; Bone resorption; IGF-1.

Publication types

Review

MeSH terms

Animals
Bone Density
Bone Resorption*
Bone and Bones / metabolism
Humans
Insulin-Like Growth Factor I* / genetics
Insulin-Like Growth Factor I* / metabolism
Insulin-Like Growth Factor II / metabolism

Substances

Insulin-Like Growth Factor I
Insulin-Like Growth Factor II