Elevated body mass index increased the risk of recurrence in Chinese patients with chronic rhinosinusitis

Shaobing Xie; Sijie Jiang; Ruohao Fan; Kelei Gao; Jian Shui; Fengjun Wang; Zhihai Xie; Hua Zhang; Weihong Jiang

doi:10.1016/j.amjoto.2023.103841

Elevated body mass index increased the risk of recurrence in Chinese patients with chronic rhinosinusitis

Am J Otolaryngol. 2023 Jul-Aug;44(4):103841. doi: 10.1016/j.amjoto.2023.103841. Epub 2023 Mar 18.

Authors

Shaobing Xie¹, Sijie Jiang¹, Ruohao Fan¹, Kelei Gao¹, Jian Shui², Fengjun Wang¹, Zhihai Xie¹, Hua Zhang³, Weihong Jiang⁴

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China; Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China; Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China.
² Clinical Laboratory, Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, People's Republic of China.
³ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China; Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China; Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. Electronic address: entxy@126.com.
⁴ Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, Changsha, People's Republic of China; Hunan Province Key Laboratory of Otolaryngology Critical Diseases, Xiangya Hospital of Central South University, Changsha, People's Republic of China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, People's Republic of China; Anatomy Laboratory of Division of Nose and Cranial Base, Clinical Anatomy Center of Xiangya Hospital, Central South University, Changsha, People's Republic of China. Electronic address: jiangwh68@126.com.

PMID: 36948079
DOI: 10.1016/j.amjoto.2023.103841

Abstract

Background: Elevated body mass index (BMI) has been associated with an increased prevalence of chronic rhinosinusitis (CRS). However, the impact of BMI on the risk of recurrence of CRS is unknown. This study aimed to investigate the association between BMI and the risk of CRS recurrence.

Material and methods: A retrospective cohort study was conducted and recruited 1057 CRS patients who underwent functional endoscopic sinus surgery (FESS). All subjects were classified into four groups: "underweight", "normal weight", "overweight", and "obese". Multivariate regression analysis was performed to examine the associations between BMI categories and other factors and the risk of CRS recurrence.

Results: The rate of recurrent CRS was significantly higher in the overweight group and obese group than in the normal weight group (P < 0.05). Unadjusted and adjusted logistic regression analyses demonstrated that overweight and obesity exhibited an increased risk of CRS recurrence as compared to patients with normal weight (P < 0.05). Furthermore, all patients were divided into primary CRS group and recurrent CRS group, and the BMI, duration of disease and rate of allergic rhinitis were vastly increased in the recurrent group than in the primary group (P < 0.05). Univariate and multivariate regression analysis showed that BMI and duration of disease were the dominant risk factors of CRS recurrence (P < 0.05).

Conclusion: Overweight and obesity presented significant impacts on the CRS recurrence, and elevated BMI were associated with an increased risk of CRS recurrence independently from traditional risk factors. A longer duration of disease was correlated with a higher risk of CRS recurrence.

Keywords: Body mass index; Chronic rhinosinusitis; Obesity; Overweight; Recurrence.

MeSH terms

Body Mass Index*
Chronic Disease
East Asian People*
Humans
Obesity / complications
Obesity / epidemiology
Overweight / complications
Overweight / epidemiology
Retrospective Studies
Rhinitis* / complications
Rhinitis* / epidemiology
Risk Factors
Sinusitis* / complications
Sinusitis* / epidemiology