Recent Advances in Metal Free Synthesis of N-unsubstituted 1,2,3-Triazoles

Abstract

1, 2, 3-triazoles display enormous applications in the extensive fields of chemistry such as pharmaceuticals, ligands, conjectures, etc. Among these classes of compounds, the N-unsubstituted triazole emerges as a potent applicant for various fields of chemistry and therefore synthetic procedures for this molecular scaffold possess certain importance. Moreover, from an environmental perspective, metal-free organic synthesis gains tremendous attention as most of the metals are persistent in nature. In this review, we are going to discuss only the metal-free synthetic routes for the construction of N-unsubstituted 1,2,3-triazoles reported during the last decade.

Keywords: Synthesis; green; heterocycle; metal free; toxicity; triazoles.