1 Peninsula Medical School, University of Plymouth, John Bull Building, Tamar Science Park, Plymouth, PL6 8BU, UK. daniel.martin@plymouth.ac.uk.
2 Intensive Care Unit, University Hospitals Plymouth, Derriford Road, Plymouth, Devon, PL6 8DH, UK. daniel.martin@plymouth.ac.uk.
3 Department of Anaesthesia and Intensive Care Unit, Regional University Hospital of Montpellier, St-Eloi Hospital, University of Montpellier, PhyMedExp, INSERM U1046, CNRS UMR, 9214, Montpellier CEDEX 5, France.
4 Institut Für Anästhesiologische Pathophysiologie und Verfahrensentwicklung, Universitätsklinikum, Helmholtzstrasse 8-1, 89081, Ulm, Germany.