The Hippo signaling pathway: from multiple signals to the hallmarks of cancers

Ning Zhu; Ruizeng Yang; Xiaodong Wang; Liang Yuan; Xiaoyu Li; Fang Wei; Lei Zhang

doi:10.3724/abbs.2023035

The Hippo signaling pathway: from multiple signals to the hallmarks of cancers

Acta Biochim Biophys Sin (Shanghai). 2023 Mar 20;55(6):904-913. doi: 10.3724/abbs.2023035.

Authors

Ning Zhu^{1

2

3}, Ruizeng Yang², Xiaodong Wang^{2

4}, Liang Yuan^{2

4}, Xiaoyu Li², Fang Wei³, Lei Zhang^{1

2

3

5

4}

Affiliations

¹ School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
² State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.
³ Sheng Yushou Center of Cell Biology and Immunology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China.
⁴ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
⁵ School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Hangzhou 310024, China.

Abstract

Evolutionarily conserved, the Hippo signaling pathway is critical in regulating organ size and tissue homeostasis. The activity of this pathway is tightly regulated under normal circumstances, since its physical function is precisely maintained to control the rate of cell proliferation. Failure of maintenance leads to a variety of tumors. Our understanding of the mechanism of Hippo dysregulation and tumorigenesis is becoming increasingly precise, relying on the emergence of upstream inhibitor or activator and the connection linking Hippo target genes, mutations, and related signaling pathways with phenotypes. In this review, we summarize recent reports on the signaling network of the Hippo pathway in tumorigenesis and progression by exploring its critical mechanisms in cancer biology and potential targeting in cancer therapy.

Keywords: Hippo; TAZ; TEAD; YAP; cancer; hallmark; signal transduction.

Publication types

Review

MeSH terms

Carcinogenesis / genetics
Hippo Signaling Pathway*
Humans
Intracellular Signaling Peptides and Proteins / genetics
Intracellular Signaling Peptides and Proteins / metabolism
Neoplasms* / genetics
Neoplasms* / pathology
Protein Serine-Threonine Kinases / metabolism
Trans-Activators / metabolism
Transcriptional Coactivator with PDZ-Binding Motif Proteins
YAP-Signaling Proteins

Substances

Protein Serine-Threonine Kinases
Intracellular Signaling Peptides and Proteins
Trans-Activators
Transcriptional Coactivator with PDZ-Binding Motif Proteins
YAP-Signaling Proteins

Grants and funding

This work was supported by the grants from the National Key Research and Development Program of China (No. 2019YFA0802001 to L.Z.), the National Natural Science Foundation of China (Nos. 32030025, 32293233 and 32221002 to L.Z., and No. 32270763 to N.Z.), the Shanghai Municipal Science and Technology Major Project, and the Shanghai Leading Talents Program to L.Z.