Therapeutic potential of naringin in improving the survival rate of skin flap: A review

Yincang Wang; Xiaodong Li; Hang Lv; Lin Sun; Bo Liu; Xiaofeng Zhang; Xilin Xu

doi:10.3389/fphar.2023.1128147

Therapeutic potential of naringin in improving the survival rate of skin flap: A review

Front Pharmacol. 2023 Mar 2:14:1128147. doi: 10.3389/fphar.2023.1128147. eCollection 2023.

Authors

Yincang Wang¹, Xiaodong Li², Hang Lv², Lin Sun¹, Bo Liu¹, Xiaofeng Zhang³, Xilin Xu²

Affiliations

¹ Heilongjiang University of Chinese Medicine, Harbin, China.
² The Third Department of Orthopedics and Traumatology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
³ Teaching and Research Section of Orthopedics and Traumatology, Heilongjiang University of Chinese Medicine, Harbin, China.

Abstract

Naringin is the main component of Drynaria. Modern pharmacological studies have shown that naringin has a wide range of pharmacological activities, including antioxidant, anti-inflammatory, anti-apoptotic, anti-ulcer, and anti-osteoporosis effects. Its therapeutic effects have been observed in various clinical models, such as atherosclerosis, cardiovascular diseases, diabetes, neurodegenerative diseases, and rheumatic diseases. This review investigates the pharmacological effects of naringin and the associated mechanisms in improving flap survival. This review will also provide a reference for future rational application of naringin, especially in research to improve flap survival.

Keywords: VEGF; angiogenesis; inflammation; naringin; skin flap survival.

Publication types

Review

Grants and funding

The State Administration of Traditional Chinese Medicine Construction Project of Inheritance Studio of National Famous Traditional Chinese Medicine Experts (No. 2021-2024). Youth Qihuang Scholar Support Project of the State Administration of Troditional Chinese Medicine (No. 2021-2023). Key Laboratory ofBasic and Clinical Research of Osteonecrosis in Heilongjiang Province.