Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing

Yanping Feng; Mingzhen Wu; Haidong Zhang; He Xu; Huili Li; Dongmin Chen; Hongyi Jiang; Jiang Chang; Zhihong Dong; Chen Yang

doi:10.3389/fbioe.2023.1158007

Mild-temperature photothermal assisted CuSi nanowires for promoting infected wound healing

Front Bioeng Biotechnol. 2023 Mar 3:11:1158007. doi: 10.3389/fbioe.2023.1158007. eCollection 2023.

Authors

Yanping Feng^{1

2

3}, Mingzhen Wu^{4

3}, Haidong Zhang⁵, He Xu⁴, Huili Li^{2

3}, Dongmin Chen^{2

3}, Hongyi Jiang³, Jiang Chang^{2

3

4}, Zhihong Dong¹, Chen Yang^{2

3}

Affiliations

¹ College of Mechanical Engineering, Chengdu University, Chengdu, Sichuan, China.
² Joint Centre of Translational Medicine, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
³ Zhejiang Engineering Research Center for Tissue Repair Materials, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
⁴ College of Chemistry and Materials Sciences, Shanghai Normal University, Shanghai, China.
⁵ Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.

Abstract

In clinical practice, the utilization of antibiotics is still the main approach for the treatment of wound contamination, which lacks the ability to accelerate wound healing and arises the global concern of antimicrobial resistance. Plenty of alternative methods have been explored in recent years due to the fast development of material science. Here, CuO/SiO₂ nanowires (CuSi NWs) with good near-infrared (NIR) photothermal conversion ability are synthesized by a one-step hydrothermal method. The as-prepared CuSi NWs possess excellent antibacterial ability against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), which could be enhanced by the assistance of mild photothermal therapy (PTT). Moreover, CuSi NWs at suitable concentrations can promote proliferation, migration, and angiogenic gene expression of human umbilical vein endothelial cells (HUVECs), exhibiting a remarkable pro-vascularization ability. The in vivo mouse infect model further proves that the CuSi NWs might be a good candidate for the treatment of infected wounds as the high antibacterial efficiency and accelerated wound healing is obtained.

Keywords: angiogenesis; anti-bacteria; infected wound; nanowire; photothermal therapy.

Grants and funding

This research was supported by National Natural Science Foundation of China (32271386), the Wenzhou Science and Technology Major Project (ZY2022028), the Wenzhou Science and Technology Project (Y20220142), Chengdu Municipal Technological Innovation R&D Project (2021-YF05-01871-SN), Project of Chengdu Municipal Health Commission (2021059), Zhejiang Engineering Research Center for Tissue Repair Materials (WIUCASZZXF21001), the seed grants from the Wenzhou Institute, University of Chinese Academy of Sciences (WIUCASQD2020013, WIUCASQD2021030), and the funding from the First Affiliated Hospital of Wenzhou Medical University.