Prenylated indole-terpenoids with antidiabetic activities from Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne

Xijin Liu; Fandong Kong; Na Xiao; Xiaoyu Li; Mingyu Zhang; Fujin Lv; Xiaolin Liu; Xiangchuan Kong; Jing Bi; Xinyi Lu; Daqing Kong; Gangping Hao; Liman Zhou; Guojun Pan

doi:10.3389/fmicb.2023.1099103

Prenylated indole-terpenoids with antidiabetic activities from Penicillium sp. HFF16 from the rhizosphere soil of Cynanchum bungei Decne

Front Microbiol. 2023 Mar 2:14:1099103. doi: 10.3389/fmicb.2023.1099103. eCollection 2023.

Authors

Xijin Liu¹, Fandong Kong², Na Xiao³, Xiaoyu Li¹, Mingyu Zhang¹, Fujin Lv¹, Xiaolin Liu¹, Xiangchuan Kong¹, Jing Bi¹, Xinyi Lu¹, Daqing Kong¹, Gangping Hao¹, Liman Zhou², Guojun Pan¹

Affiliations

¹ College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an, Shandong, China.
² Key Laboratory of Chemistry and Engineering of Forest Products, State Ethnic Affairs Commission, Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products, School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning, China.
³ State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agriculture University, Tai'an, Shandong, China.

Abstract

Finding novel and effective suppression of hepatic glucagon response antidiabetic compounds is urgently required for the development of new drugs against diabetes. Fungi are well known for their ability to produce new bioactive secondary metabolites. In this study, four new prenylated indole-terpenoids (1-4), named encindolenes I-L, as well as a known analogue (5), were isolated from the fungus Penicillium sp. HFF16from the rhizosphere soil of Cynanchum bungei Decne. The structures of the compounds were elucidated by spectroscopic data and ECD analysis. In the antidiabetic activity assay, compounds 1-5 could inhibit glucagon-induced hepatic glucose output with EC₅₀ values of 67.23, 102.1, 49.46, 25.20, and 35.96 μM, respectively, and decrease the intracellular cAMP contents in primary hepatocytes.

Keywords: Antidiabetic activity; Cynanchum bungei Decne; Penicillium sp. HFF16; fungus; indole-terpenoids.