Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review

Cuihua Liu; Zunjiang Li; Botao Li; Wei Liu; Shizhong Zhang; Kuncheng Qiu; Wei Zhu

doi:10.7717/peerj.14952

Relationship between ferroptosis and mitophagy in cardiac ischemia reperfusion injury: a mini-review

PeerJ. 2023 Mar 13:11:e14952. doi: 10.7717/peerj.14952. eCollection 2023.

Authors

Cuihua Liu¹, Zunjiang Li², Botao Li¹, Wei Liu¹, Shizhong Zhang¹, Kuncheng Qiu¹, Wei Zhu²

Affiliations

¹ Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine, Medical College, China Three Gorges University, Yichang, Hubei Province, China.
² The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China.

Abstract

Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people's life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients. Studying the mechanisms of MIRI can help us improve the treatment of MIRI. The pathological process of MIRI involves many mechanisms such as ferroptosis and mitophagy. Ferroptosis can exacerbate MIRI, and regulation of mitophagy can alleviate MIRI. Both ferroptosis and mitophagy are closely related to ROS, but there is no clear understanding of the relationship between ferroptosis and mitophagy. In this review, we analyzed the relationship between ferroptosis and mitophagy according to the role of mTOR, NLPR3 and HIF. In addition, simultaneous regulation of mitophagy and ferroptosis may be superior to single therapy for MIRI. We summarized potential drugs that can regulate mitophagy and/or ferroptosis, hoping to provide reference for the development of drugs and methods for MIRI treatment.

Keywords: Ferroptosis; Mechanism; Mitophagy; Myocardial ischemia reperfusion injury; Relationship.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Ferroptosis*
Humans
Mitophagy
Myocardial Infarction* / pathology
Myocardial Reperfusion Injury* / drug therapy
Myocardium / pathology

Grants and funding

This work was supported by the Special Fund for Talents of China Three Gorges University (1910103), the Science and Technology Bureau of Guangzhou City School (college) co-funded Project (202201020296), and the Guangdong Provincial Hospital of Chinese Medicine Science and Technology Research Program (YN2019MJ11). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.