Molecularly imprinted polymers for the recognition of biomarkers of certain neurodegenerative diseases

Greta Pilvenyte; Vilma Ratautaite; Raimonda Boguzaite; Urte Samukaite-Bubniene; Deivis Plausinaitis; Almira Ramanaviciene; Mikhael Bechelany; Arunas Ramanavicius

doi:10.1016/j.jpba.2023.115343

Molecularly imprinted polymers for the recognition of biomarkers of certain neurodegenerative diseases

J Pharm Biomed Anal. 2023 May 10:228:115343. doi: 10.1016/j.jpba.2023.115343. Epub 2023 Mar 14.

Authors

Greta Pilvenyte¹, Vilma Ratautaite², Raimonda Boguzaite¹, Urte Samukaite-Bubniene³, Deivis Plausinaitis⁴, Almira Ramanaviciene⁵, Mikhael Bechelany⁶, Arunas Ramanavicius⁷

Affiliations

¹ Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology, Saulėtekio av. 3, LT-10257 Vilnius, Lithuania.
² Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology, Saulėtekio av. 3, LT-10257 Vilnius, Lithuania; Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania. Electronic address: raimonda.boguzaite@ftmc.lt.
³ Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology, Saulėtekio av. 3, LT-10257 Vilnius, Lithuania; Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania.
⁴ Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania.
⁵ NanoTechnas - Center of Nanotechnology and Materials Science, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania.
⁶ Institut Européen des Membranes, IEM, UMR 5635, University of Montpellier, CNRS, ENSCM, 34090 Montpellier, France.
⁷ Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology, Saulėtekio av. 3, LT-10257 Vilnius, Lithuania; Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko Str. 24, LT-03225 Vilnius, Lithuania. Electronic address: arunas.ramanavicius@chf.vu.lt.

PMID: 36934618
DOI: 10.1016/j.jpba.2023.115343

Abstract

The appearance of the biomarkers in body fluids like blood, urine, saliva, tears, etc. can be used for the identification of many diseases. This article aimed to summarize the studies about electrochemical biosensors with molecularly imprinted polymers as sensitive and selective layers on the electrode to detect protein-based biomarkers of such neurodegenerative diseases as Alzheimer's disease, Parkinson's disease, and stress. The main attention in this article is focused on the detection methods of amyloid-β oligomers and p-Tau which are representative biomarkers for Alzheimer's disease, α-synuclein as the biomarker of Parkinson's disease, and α-amylase and lysozyme as the biomarkers of stress using molecular imprinting technology. The research methods, the application of different electrodes, the influence of the polymers, and the established detection limits are reviewed and compared.

Keywords: Alzheimer’s disease biomarker; Electrochemical biosensor; Molecularly imprinted polymer (MIP); Parkinson’s disease biomarker.

Publication types

Review

MeSH terms

Alzheimer Disease* / diagnosis
Biomarkers
Electrochemical Techniques / methods
Electrodes
Humans
Molecular Imprinting* / methods
Molecularly Imprinted Polymers
Neurodegenerative Diseases* / diagnosis
Parkinson Disease*

Substances

Molecularly Imprinted Polymers
Biomarkers