Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome-Associated Colorectal Carcinomas

Noah C Helderman; Anne-Sophie Van Der Werf-'t Lam; MSH6 TUMOR GROUP; Hans Morreau; Arnoud Boot; Tom Van Wezel; Maartje Nielsen

doi:10.1053/j.gastro.2023.03.198

Molecular Profile of MSH6-Associated Colorectal Carcinomas Shows Distinct Features From Other Lynch Syndrome-Associated Colorectal Carcinomas

Gastroenterology. 2023 Jul;165(1):271-274.e2. doi: 10.1053/j.gastro.2023.03.198. Epub 2023 Mar 15.

Authors

Noah C Helderman¹, Anne-Sophie Van Der Werf-'t Lam²; MSH6 TUMOR GROUP; Hans Morreau⁶, Arnoud Boot¹⁷, Tom Van Wezel⁶, Maartje Nielsen¹⁸

Collaborators

MSH6 TUMOR GROUP:
Diantha Terlouw³, Sanne W Bajwa-Ten Broeke⁴, Mar Rodríguez-Girondo⁵, Demi van Egmond⁶, Alexandra M J Langers⁷, Monique E van Leerdam⁸, Emily Rayner⁹, Christi J van Asperen², Liselotte P van Hest¹⁰, Hans J P Gille¹⁰, Floor A M Duijkers¹¹, Anja Wagner¹², Ellis L Eikenboom¹³, Tom G W Letteboer¹⁴, Mirjam M de Jong⁴, Fonnet E Bleeker¹⁵, Encarna B Gomez Garcìa¹⁶, Manon Suerink², Carli M Tops², Niels de Wind⁹

Affiliations

¹ Department of Clinical Genetics Leiden University Medical Center Leiden, The Netherlands.
² Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
³ Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
⁴ Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
⁵ Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
⁶ Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
⁷ Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.
⁸ Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands; Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
⁹ Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
¹⁰ Department of Clinical Genetics, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam and location University of Amsterdam, Amsterdam, The Netherlands.
¹¹ Department of Human Genetics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
¹² Department of Clinical Genetics, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
¹³ Department of Clinical Genetics, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands; Department of Gastroenterology and Hepatology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
¹⁴ Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
¹⁵ Department of Clinical Genetics, Netherlands Cancer Institute, Amsterdam, The Netherlands.
¹⁶ Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, The Netherlands.
¹⁷ Genomescan, Leiden, The Netherlands.
¹⁸ Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: m.nielsen@lumc.nl.

PMID: 36931573
DOI: 10.1053/j.gastro.2023.03.198

No abstract available

MeSH terms

Biomarkers, Tumor / genetics
Colorectal Neoplasms* / genetics
Colorectal Neoplasms* / pathology
Colorectal Neoplasms, Hereditary Nonpolyposis* / genetics
Colorectal Neoplasms, Hereditary Nonpolyposis* / pathology
DNA Mismatch Repair / genetics
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
Humans
MutL Protein Homolog 1 / genetics

Substances

Biomarkers, Tumor
DNA-Binding Proteins
MutL Protein Homolog 1