HK2: Gatekeeping microglial activity by tuning glucose metabolism and mitochondrial functions

Jing Fang; Shudi Luo; Zhimin Lu

doi:10.1016/j.molcel.2023.02.022

HK2: Gatekeeping microglial activity by tuning glucose metabolism and mitochondrial functions

Mol Cell. 2023 Mar 16;83(6):829-831. doi: 10.1016/j.molcel.2023.02.022.

Authors

Jing Fang¹, Shudi Luo², Zhimin Lu³

Affiliations

¹ Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, Shandong 266071, China.
² Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China.
³ Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China. Electronic address: zhiminlu@zju.edu.cn.

PMID: 36931254
DOI: 10.1016/j.molcel.2023.02.022

Abstract

Hexokinase 2 (HK2) plays a multifaceted role in the regulation of cellular activities. A new study by Hu et al.¹ delineated a critical role of HK2 in governing glycolytic flux and mitochondrial activity, thereby modulating microglial functions in maladaptive inflammation in brain diseases.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gatekeeping
Glucose / metabolism
Glycolysis / physiology
Hexokinase* / genetics
Hexokinase* / metabolism
Microglia* / metabolism
Mitochondria / metabolism

Substances

Hexokinase
Glucose