TGF-β1 ameliorates BBB injury and improves long-term outcomes in mice after ICH

Huimei Wen; Jiaying Tan; Mi Tian; Yao Wang; Yanqin Gao; Ye Gong

doi:10.1016/j.bbrc.2023.03.007

TGF-β1 ameliorates BBB injury and improves long-term outcomes in mice after ICH

Biochem Biophys Res Commun. 2023 Apr 30:654:136-144. doi: 10.1016/j.bbrc.2023.03.007. Epub 2023 Mar 6.

Authors

Huimei Wen¹, Jiaying Tan¹, Mi Tian¹, Yao Wang¹, Yanqin Gao², Ye Gong³

Affiliations

¹ Department of Critical Care Medicine and Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China.
² Department of Critical Care Medicine and Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. Electronic address: yqgao@shmu.edu.cn.
³ Department of Critical Care Medicine and Neurosurgery of Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai, China. Electronic address: gong_ye@fudan.edu.cn.

PMID: 36931108
DOI: 10.1016/j.bbrc.2023.03.007

Abstract

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke characterized by high mortality and morbidity rates with no effective treatment. TGF-β/ALK-5 signaling is reported to participated in the regulation of blood-brain barrier (BBB) integrity in the inflammation pain model, the effects of transforming growth factor (TGF)-β1 and the potential mechanisms on BBB after ICH have not been fully elucidated. Herein, we have demonstrated that peripheral administration of TGF-β1 reduces brain edema and ameliorated BBB injury after ICH. Consistent with previous results, TGF-β1 is shown to promote activation of anti-inflammatory microglia and reduce the inflammatory response after ICH. Furthermore, TGF-β1 administration improves long-term outcomes after ICH. Our data suggest that TGF-β1 may be a promising therapeutic agent for ICH.

Keywords: Blood-brain barrier; Intracerebral hemorrhage; Microglia/macrophage; Neuroinflammation; TGF-β1.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood-Brain Barrier / metabolism
Brain Edema* / drug therapy
Brain Edema* / metabolism
Cerebral Hemorrhage / drug therapy
Cerebral Hemorrhage / metabolism
Mice
Signal Transduction
Stroke* / metabolism
Transforming Growth Factor beta1 / metabolism

Substances

Transforming Growth Factor beta1