Compared with rodents, pigs are closer to humans in terms of anatomy, metabolism and physiology, so they are ideal animal models of human diseases and xenotransplantation donors. In addition, as one of the most important livestock in China, pigs are closely related to our lives in terms of breeding improvement, disease prevention and animal welfare. In this review, we mainly summarize the research progress and future application of genetically modified pig models in the fields of xenotransplantation, molecular breeding and human disease models. We wish to take this opportunity to raise the awareness of researchers in related fields on cutting-edge technologies such as gene editing and understand the significance of genetically modified pig models in life science research.
猪在解剖结构、代谢、生理生化等特征方面比啮齿类动物更接近人类，因此在模拟某些人类疾病以及提供异种移植器官等方面具有其他动物不可替代的优势，是理想的人类疾病动物模型和异种器官的供体。另外，猪作为我国畜牧业最重要的物种之一，猪的品种改良、疫病防控以及动物福利等问题都与人民生活息息相关。本文主要介绍了遗传修饰猪模型在分子育种、人类疾病模型以及异种器官移植领域的研究进展及未来应用前景，希望增进相关领域研究人员对基因编辑等前沿技术的了解，理解遗传修饰猪模型在生命科学研究中的重要意义。.
Keywords: disease models; genetically modified pig models; molecular breeding; xenotransplantation.