America's science, technology, and innovation ecosystem is a powerful engine for progress, but it was conceived in the last century for last century's goals. Today, the nation's aspirations have never been bigger: robust health and ample opportunity for everyone, tackling the climate crisis and using it to reimagine infrastructure and humanity's relationship with nature, global security and stability, a competitive economy that creates good-paying jobs, and a strong, thriving democracy. The purpose of science and technology is to open the doors that make these aspirations possible. As President Biden said, "We can channel the full talents of all our people into a greater measure of hope and opportunity for our nation and for the world."