Palladium-Catalyzed Oxidative Annulation Leading to Substituted Pyrrolo[3,2,1- jk]carbazoles by Sequential C-N and C-C Bond Formation

Org Lett. 2023 Mar 24;25(11):1823-1828. doi: 10.1021/acs.orglett.3c00244. Epub 2023 Mar 16.

Abstract

A novel regioselective annulation of propargylic alcohols with simple carbazoles for the construction of [3,2,1-jk]carbazole scaffolds is described to be the first example of intermolecular synthesis of [3,2,1-jk]carbazoles from simple carbazoles. In situ synthesis of propargyl alcohols from simple, cheap, and easily accessible ketones has also been developed during the one-pot synthesis of [3,2,1-jk]carbazoles.