Effects of Supplemental Oxygen on Cardiovascular and Respiratory Interactions by Extended Partial Directed Coherence in Idiopathic Pulmonary Fibrosis

Laura M Santiago-Fuentes; Sonia Charleston-Villalobos; Ramón González-Camarena; Andreas Voss; Mayra E Mejía-Avila; Ivette Buendía-Roldan; Sina Reulecke; Tomás Aljama-Corrales

doi:10.3389/fnetp.2022.834056

Effects of Supplemental Oxygen on Cardiovascular and Respiratory Interactions by Extended Partial Directed Coherence in Idiopathic Pulmonary Fibrosis

Front Netw Physiol. 2022 Mar 15:2:834056. doi: 10.3389/fnetp.2022.834056. eCollection 2022.

Authors

Laura M Santiago-Fuentes¹, Sonia Charleston-Villalobos¹, Ramón González-Camarena², Andreas Voss³, Mayra E Mejía-Avila⁴, Ivette Buendía-Roldan⁴, Sina Reulecke¹, Tomás Aljama-Corrales¹

Affiliations

¹ Electrical Engineering Department, Universidad Autónoma Metropolitana, Mexico City, Mexico.
² Health Science Department, Universidad Autónoma Metropolitana, Mexico City, Mexico.
³ Institute of Biomedical Engineering and Informatics, University of Technology Ilmenau, Ilmenau, Germany.
⁴ National Institute of Respiratory Diseases, Mexico City, Mexico.

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic and restrictive disease characterized by fibrosis and inflammatory changes in lung tissue producing a reduction in diffusion capacity and leading to exertional chronic arterial hypoxemia and dyspnea. Furthermore, clinically, supplemental oxygen (SupplO₂) has been prescribed to IPF patients to improve symptoms. However, the evidence about the benefits or disadvantages of oxygen supplementation is not conclusive. In addition, the impact of SupplO₂ on the autonomic nervous system (ANS) regulation in respiratory diseases needs to be evaluated. In this study the interactions between cardiovascular and respiratory systems in IPF patients, during ambient air (AA) and SupplO₂ breathing, are compared to those from a matched healthy group. Interactions were estimated by time series of successive beat-to-beat intervals (BBI), respiratory amplitude (RESP) at BBI onset, arterial systolic (SYS) and diastolic (DIA) blood pressures. The paper explores the Granger causality (GC) between systems in the frequency domain by the extended partial directed coherence (ePDC), considering instantaneous effects. Also, traditional linear and nonlinear markers as power in low (LF) and high frequency (HF) bands, symbolic dynamic indices as well as arterial baroreflex, were calculated. The results showed that for IPF during AA phase: 1) mean BBI and power of BBI-HF band, as well as mean respiratory frequency were significantly lower (p < 0.05) and higher (p < 0.001), respectively, indicating a strong sympathetic influence, and 2) the RESP $\to$ SYS interaction was characterized by Mayer waves and diminished RESP $\to$ BBI, i.e., decreased respiratory sinus arrhythmia. In contrast, during short-term SupplO₂ phase: 1) oxygen might produce a negative influence on the systolic blood pressure variability, 2) the arterial baroreflex reduced significantly (p < 0.01) and 3) reduction of RSA reflected by RESP $\to$ BBI with simultaneous increase of Traube-Hering waves in RESP $\to$ SYS (p < 0.001), reflected increased sympathetic modulation to the vessels. The results gathered in this study may be helpful in the management of the administration of SupplO₂.

Keywords: extended partial directed coherence; idiopathic pulmonary fibrosis; supplemental oxygen; systems interactions; time-frequency cardiorespiratory interactions.